肿瘤进展
转移
骨桥蛋白
癌症研究
头颈部鳞状细胞癌
基因沉默
癌症
转录因子
医学
生物
头颈部癌
内科学
基因
生物化学
作者
Kai Li,Huiying Hu,Haolin Jiang,Haidong Zhang,Shanchun Gong,Dongmin Wei,Zhenkun Yu
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:2020-11-11
卷期号:42 (3): 414-422
被引量:20
标识
DOI:10.1093/carcin/bgaa116
摘要
Abstract Tumor progression and metastasis are still major burdens for head and neck squamous cell carcinoma (HNSCC). Runt-related transcription factor 1 (RUNX1) is involved in aggressive phenotypes in several cancers, while the molecular role of RUNX1 underlying cancer progression and metastasis of HNSCC remains largely unknown. In our study, RUNX1 expression was increased with disease progression in patients with HNSCC. The silencing of RUNX1 significantly decelerated the malignant progression of HNSCC cells, reduced osteopontin (OPN) expression in vitro and weakened the tumorigenicity of HNSCC cells in vivo. Moreover, we demonstrated that RUNX1 activated the mitogen-activated protein kinase signaling by directly binding to the promoter of OPN in tumor progression and metastasis of HNSCC. Our results may provide new insight into the mechanisms underlying the role of RUNX1 in tumor progression and metastasis and reveal the potential therapeutic target in HNSCC.
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