医学
血沉
内科学
川崎病
胃肠病学
中性粒细胞与淋巴细胞比率
接收机工作特性
单变量分析
白蛋白
C反应蛋白
抗体
贫血
白细胞
入射(几何)
免疫学
淋巴细胞
炎症
多元分析
动脉
物理
光学
作者
Gang Li,Ting Wang,Yongying Gou,Rumeng Zeng,Dong Liu,Dan Yan,Bin Liu
标识
DOI:10.1016/j.intimp.2020.107037
摘要
C-reactive protein/albumin ratio (CAR) is associated with inflammation. However, it prognostic value for intravenous immunoglobulin (IVIG) resistant Kawasaki disease (KD) has scarcely investigated. A total of 957 patients with KD including 159 IVIG-resistant patients and 798 with IVIG-responsive patients between Jun 2013 and August 2019 were reviewed and the laboratory records were compared between IVIG-resistant patients and IVIG-responsive patients. Univariate and multivariate logistic analysis were performed to determine the independent predictors of IVIG resistance. A receiver operating characteristic curve analysis was conducted to compare the predictive accuracy between CAR and the combination of neutrophil-to-lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). High CAR was associated with high the incidence of IVIG-resistance, anemia and coronary artery lesions, and high levels of neutrophils, CRP, aspartate aminotransferase, NLR, PLR, and erythrocyte sedimentation rate, and associated with low levels hemoglobin, albumin and lymphocytes count (all p < 0.05). The CAR (OR: 1.33, CI: 1.09–1.57), NLR (OR: 1.02, CI: 1.002–1.039) and PLR (OR: 1.004, CI: 1.003–1.005) were independent predictors for IVIG-resistance. CAR has superior discriminatory ability for IVIG resistance when compared with combination of NLR and PLR (z = 2.575, p = 0.01). CAR prior to IVIG treatment could be a novel prognostic marker for IVIG resistant KD. CAR was superior to the combination of NLR and PLR for predicting IVIG resistant KD.
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