伤害
原肌球蛋白受体激酶B
脑源性神经营养因子
神经营养素
神经科学
神经病理性疼痛
慢性疼痛
心理学
医学
内科学
神经营养因子
受体
作者
Natalia Cappoli,Elisabetta Tabolacci,Paola Aceto,Cinzia Dello Russo
标识
DOI:10.1016/j.jneuroim.2020.577406
摘要
The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in peripheral and central nervous system (CNS). Despite evidence of a pro-nociceptive role of BDNF, recent studies have reported contrasting results, including anti-nociceptive and anti-inflammatory activities. Moreover, BDNF polymorphisms can interfere with BDNF role in pain perception. In Val66Met carriers, the Met allele may have a dual role, with anti-nociceptive actions in normal condition and pro-nociceptive effects during chronic pain. In order to elucidate the main effects of BDNF in nociception, we reviewed the main characteristics of this neurotrophin, focusing on its involvement in pain.
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