脂肪组织
调解人
代谢调节
代谢综合征
内分泌学
白色脂肪组织
纤维连接蛋白
医学
内科学
激素
生物信息学
生物
生物化学
肥胖
新陈代谢
细胞外基质
作者
Jing‐Fu Bao,Qin-Ying She,Panpan Hu,Jun Nan,Aiqing Li
标识
DOI:10.1016/j.tem.2022.06.003
摘要
Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a mediator of exercise-induced metabolic improvements, such as browning of white adipose tissue, and is known to alleviate several chronic non-metabolic diseases. Thus, irisin may be an ideal therapeutic target for metabolic and non-metabolic diseases. However, several controversies regarding irisin have hindered its clinical translation. We review the generation, regulation (especially in exercise), and metabolic as well as therapeutic effects of irisin on metabolic and non-metabolic diseases. Furthermore, we discuss controversies regarding irisin and highlight potential future research directions.
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