微生物群
肠道微生物群
肠道菌群
某种肠道细菌
基因组
生物
粪便
拟杆菌
过境时间
计算生物学
微生物学
胃肠道
医学
生物信息学
免疫学
遗传学
细菌
工程类
基因
运输工程
作者
Francesco Asnicar,Emily R Leeming,Eirini Dimidi,Mohsen Mazidi,Paul W. Franks,Haya Al Khatib,Ana M. Valdes,Richard Davies,Elco Bakker,Lucy Francis,Andrew T. Chan,Rachel Gibson,George Hadjigeorgiou,Jonathan Wolf,Timothy D. Spector,Nicola Segata,Sarah Berry
出处
期刊:Gut
[BMJ]
日期:2021-03-15
卷期号:70 (9): 1665-1674
被引量:59
标识
DOI:10.1136/gutjnl-2020-323877
摘要
Background and aims Gut transit time is a key modulator of host–microbiome interactions, yet this is often overlooked, partly because reliable methods are typically expensive or burdensome. The aim of this single-arm, single-blinded intervention study is to assess (1) the relationship between gut transit time and the human gut microbiome, and (2) the utility of the ‘blue dye’ method as an inexpensive and scalable technique to measure transit time. Methods We assessed interactions between the taxonomic and functional potential profiles of the gut microbiome (profiled via shotgun metagenomic sequencing), gut transit time (measured via the blue dye method), cardiometabolic health and diet in 863 healthy individuals from the PREDICT 1 study. Results We found that gut microbiome taxonomic composition can accurately discriminate between gut transit time classes (0.82 area under the receiver operating characteristic curve) and longer gut transit time is linked with specific microbial species such as Akkermansia muciniphila , Bacteroides spp and Alistipes spp (false discovery rate-adjusted p values <0.01). The blue dye measure of gut transit time had the strongest association with the gut microbiome over typical transit time proxies such as stool consistency and frequency. Conclusions Gut transit time, measured via the blue dye method, is a more informative marker of gut microbiome function than traditional measures of stool consistency and frequency. The blue dye method can be applied in large-scale epidemiological studies to advance diet-microbiome-health research. Clinical trial registry website https://clinicaltrials.gov/ct2/show/NCT03479866 and trial number NCT03479866 .
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