肝细胞癌
经导管动脉化疗栓塞
材料科学
钡铁氧体
铁氧体(磁铁)
纳米晶
核磁共振
生物医学工程
癌症研究
纳米技术
复合材料
医学
物理
作者
Peng Zhao,Jianhua Zhao,Yunfei Deng,Guoxun Zeng,Yuanfei Jiang,Leen Liao,Shangshang Zhang,Qiang Tao,Zonghao Liu,Xiang Tang,Xinyue Tu,Lingmin Jiang,Haiyan Zhang,Yun Zheng
标识
DOI:10.1016/j.jcis.2021.05.102
摘要
Transcatheter arterial chemoembolization (TACE) has been widely used in clinical practice as a first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the current therapeutic effect of TACE is far from satisfactory and thus requires further improvement. TACE combined with multifunctional magnetic particles may be a promising approach for the treatment of HCC. In this study, we designed a new magnetic drug carrier system consisting of micron-sized iron powder, barium ferrite (BaFe12O19), and carbon-coated iron nanocrystals (CCINs). CCINs possess properties, such as high drug loading and sustained release. BaFe12O19 could attract both CCINs and iron powder to form larger clusters after magnetization. Altogether, the triple therapeutic effects of chemotherapeutic enhancement, embolization, and thermal ablation could be realized herein. Further experiments indicate that the system has a high drug-loading capacity, good controlled-release effect, and no significant cytotoxicity. Under the action of a medium-frequency magnetic induction device, the magnetic induction temperature could reach 43 °C in one min while the maximum temperature of 70.8 °C could be reached in 2.5 h. Overall, this new carrier system displayed excellent antitumor effects in a mouse model. Our findings demonstrate the great application prospects of this system in TACE for HCC.
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