The compounds of general structure (58) have a considerable steric hindrance and are strongly resistant to the addition of a nucleophile.In this work we used only derivatives of methyl levulinate as nucleophiles ; these substrates are themselves sterically hindered, and we showed that this is not the appropriate method to add a nucleophile to compounds (85). 1-INTRODUÇÃO 6.2.9-Espectro de Massa do composto (57):CO 2 H