间充质干细胞
脚手架
材料科学
体外
细胞分化
纳米尺度
纳米技术
组织工程
干细胞
细胞
生物医学工程
细胞生物学
化学
生物
医学
基因
生物化学
作者
Matthew J. Dalby,Nikolaj Gadegaard,Rahul S. Tare,Abhay Andar,Mathis O. Riehle,Paweł Herzyk,C. D. W. Wilkinson,Richard O.C. Oreffo
出处
期刊:Nature Materials
[Springer Nature]
日期:2007-09-23
卷期号:6 (12): 997-1003
被引量:2175
摘要
A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.
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