Effect of polysacchario peptide on the immune function of patients with gastric carcinoma during operation and chemotherapy

Objective:To investigate the effect of polysacchario peptide on the immune function of patients with gastric carcinoma during operation and chemotherapy. Methods:105 cases of gastric carcinoma after operation and 32 cases of gastric carcinoma on chemotherapy were selected and randomly divided into simple operation group,operation combined with polysacchario peptide group,simple chemotherapy group and chemotherapy combined with polysacchario peptide group according to using polysacchario peptide or not,the red blood cell C3b receptor rosette (RBC-C3bRR),the red blood cell immune complex rosette (RBC-ICR),T-lymphocyte subsets and NK cell activity were determined. Results:Compared with simple operation group,the RBC-C3bRR,CD3,CD4,CD4/CD8 and NK cell activity of operation combined with polysacchario peptide group were significantly increased (P0.01),and the RBC-ICR was significantly decreased (P0.01); compared with simple chemotherapy group,the RBC-C3bRR,CD3,CD4,CD4/CD8 and NK cell activity of chemotherapy combined with polysacchario peptide group were significantly increased (P0.01),and the RBC-ICR was significantly decreased (P 0.01). Conclusion:Using polysacchario peptide may enhance the immune function of patients with gastric carcinoma during operation and chemotherapy.