Controversies and Assessments of Interaction between Clopidogrel and Proton Pump Inhibitor

Current consensus recommendations that patients prescribed clopidogrel plus aspirin should receive a proton pump inhibitor(PPI) to reduce gastrointestinal bleeding.However,recent studies have shown higher rates of adverse cardiovascular events in patients on PPI and clopidogrel,in comparison to patients on clopidogrel only.This article reviews the controversies and advances in clinical research on the interaction between clopidogrel and PPI.