Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer Pathway
作者
Susanna Plugge,H. Ma,Jelte van der Vaart,Joep Sprangers,Folkert H.M. Morsink,Despina Xanthakis,Carol Jamieson,K B W Stroot,A. Keijzer,T Margaritis,Tito Candelli,Roy Straver,J. de Ridder,F.C.R. Holstege,Wendy W.J. de Leng,G. J. A. Offerhaus,Alessandra Merenda,Madelon M. Maurice
Heterozygous loss of LKB1 pushes intestinal cells into a chronic regenerative state, which is amplified on loss of heterozygosity. Lkb1 deficiency thereby generates fertile ground for serrated colorectal cancer formation in the intestine, potentially explaining the increased cancer risk observed in PJS.
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