医学
病理生理学
疾病
缺血
心脏病学
心肌缺血
内科学
重症监护医学
出处
期刊:Med
[Elsevier]
日期:2024-01-01
卷期号:5 (1): 10-31
被引量:2
标识
DOI:10.1016/j.medj.2023.12.007
摘要
Ischemic heart disease is the greatest health burden and most frequent cause of death worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic heart disease. Improvements in prevention and treatment of ischemic heart disease have reduced mortality in developed countries over the last decades, but further progress is now stagnant, and morbidity and mortality from ischemic heart disease in developing countries are increasing. Significant problems remain to be resolved and require a better pathophysiological understanding. The present review attempts to briefly summarize the state of the art in myocardial ischemia/reperfusion research, with a view on both its coronary vascular and myocardial aspects, and to define the cutting edges where further mechanistic knowledge is needed to facilitate translation to clinical practice.
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