Where does genetic testing fit in the diagnostic pathway of patients with cryptogenic cirrhosis?

The authors have no conflicts of interest to disclose. Hepatology Genome Rounds: an interdisciplinary approach to integrate genomic data into clinical practiceJournal of HepatologyPreviewIn the last decade, the utility of whole-exome sequencing in uncovering genetic aetiologies of a variety of liver diseases has been demonstrated. These new diagnoses have guided the management, treatment, and prognostication of previously undiagnosed patients, largely thanks to improved insight into the underlying pathogenesis of their conditions. Despite its clear benefits, the uptake of genetic testing by hepatologists has been limited, in part due to limited prior genetic training and/or opportunities for continuing education. Full-Text PDF