胼胝体
部分各向异性
磁共振弥散成像
钩束
心理学
白质
神经科学
病理
医学
磁共振成像
放射科
作者
Huan Liu,Yuke Zhong,Guohui Liu,Huanhuan Su,Zhihui Liu,Jiahao Wei,Lijuan Mo,Chong-Tin Tan,Xi Liu,Lifen Chen
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2024-03-09
卷期号:35 (6): 366-373
标识
DOI:10.1097/wnr.0000000000002015
摘要
Language dysfunction is common in Parkinson’s disease (PD) patients, among which, the decline of semantic fluency is usually observed. This study aims to explore the relationship between white matter (WM) alterations and semantic fluency changes in PD patients. 127 PD patients from the Parkinson’s Progression Markers Initiative cohort who received diffusion tensor imaging scanning, clinical assessment and semantic fluency test (SFT) were included. Tract-based special statistics, automated fiber quantification, graph-theoretical and network-based analyses were performed to analyze the correlation between WM structural changes, brain network features and semantic fluency in PD patients. Fractional anisotropy of corpus callosum, anterior thalamic radiation, inferior front-occipital fasciculus, and uncinate fasciculus, were positively correlated with SFT scores, while a negative correlation was identified between radial diffusion of the corpus callosum, inferior longitudinal fasciculus, and SFT scores. Automatic fiber quantification identified similar alterations with more details in these WM tracts. Brain network analysis positively correlated SFT scores with nodal efficiency of cerebellar lobule VIII, and nodal local efficiency of cerebellar lobule X. WM integrity and myelin integrity in the corpus callosum and several other language-related WM tracts may influence the semantic function in PD patients. Damage to the cerebellum lobule VIII and lobule X may also be involved in semantic dysfunction in PD patients.
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