Neurofilament Light Chain and Differentiation of Behavioral Variant Frontotemporal Dementia From Psychiatric Disorders

The findings in this systematic review indicate that NfL may help supplement clinical diagnostic evaluations in differentiating bvFTD from psychiatric disorder diagnoses. Considering the limitations of the existing literature, future studies should prospectively recruit patients with neuropsychiatric symptoms, quantify symptom severity, obtain NfL levels in real-time using clinically available assays, consider the potential impact of patient age on diagnostic accuracy, establish clinically relevant cutoffs, and correlate NfL with autopsy-confirmed brain pathology.