Pharmacokinetics of Levofloxacin in Beagle Dogs with Intravenous Infusion

Aim To study the pharmacokinetics of Levofloxacin(LVFX) in beagle dogs. Methods Four Beagle dogs were administered with a single dose of LVFX(25mg·kg-1) by intravenous infusion(for 60min). Plasma concentration of LVFX in Beagle dogs was determined by RP-HPLC. The pharmacokinetic parameters of LVFX in Beagle dogs were calculated by 3P97 software. Results The plasma concentration-time curve of LVFX in Beagle dogs confomed to a two-compartment model. Pharmacokintic parameters were t1/2β(8.23±0.65)h,Vc(7.47±3.13)L,AUC (247.00±14.10)mg· h·L-1,Cmax (30.05±1.75)mg· L-1,respectively. Conclusion Pharmacokinetic characteristics of LVFX in Beagle dogs were similar with those of humans.