Objective To investigate the value of gastric intramucosal pH(pHi) in the early prediction of critically ill patients with multiple organ dysfunction syndrome. Methods Twenty critically ill patients's gastric intramucosal pH immediately and 24 hours later were measured,then patients were divided into multiple organ dysfunction group(group A) and non multiple organ dysfunction group(group B) according to the diagnostic standard of multiple organ dysfunction syndrome.Group A was subdivided into 2 organ dysfunction group(A1) and more than 2 organ dysfunction group(A2).Gastric intramucosal pH of group A and group B were firstly,then A1 with A2 group. Results There were 9 cases with multiple organ dysfunction syndrome.Four cases with 2 organs dysfunction,5 cases with more than 2 organs dysfunction.Gastric intramucosal pH in group A wab lower than that in group B(P0.01),gastric intramucosal pH in group A2 was lower than that in group A1(P0.01). Conclusion The level of gastric intramucosal pH was revelant to multiple organ dysfunction syndrome.It is one of the important indicators in the early prediction of critically ill patients with multiple organ dysfunction syndrome.