Brain influences of accelerated rTMS in major depression

Introduction: Accelerated repetitive transcranial magnetic stimulation paradigms have been shown to result in fast decreases in depressive symptoms and suicidal ideation. However, our knowledge how such intensified non-invasive stimulation protocols may affect neuronal processing on such short time-period is not well understood. With respect to functional connectivity, glucose metabolism and neural integrity, the subgenual anterior cingulate cortex (sgACC) has been put forward as a possible biological marker, not only to predict clinical response but also to evaluate the effects of neurostimulation treatment.