Rhodium/Gold Dual Catalysis in Carbene sp2 C−H Functionalization/Conia‐ene Cascade for the Stereoselective Synthesis of Diverse Spirocarbocycles

Abstract A Rh(II)/Au(I) catalyzed carbene cascade approach for the stereoselective synthesis of diverse spirocarbocycles is described. The cascade reaction involves a rhodium carbene initiated sp 2 C−H functionalization followed by a gold catalyzed Conia‐ene cyclization. The cascade reaction accommodates a variety of aryl substituents as well as ring sizes and proceeds with high diastereoselectivity providing access to diverse spirocarbocycles. magnified image