半乳糖凝集素
细胞生物学
细胞外基质
半乳糖凝集素-3
生物
胞浆
细胞
细胞内
免疫系统
细胞质
免疫学
生物化学
酶
作者
Ri Yao Yang,Gabriel A. Rabinovich,Fu Tong Liu
出处
期刊:Expert Reviews in Molecular Medicine
[Cambridge University Press]
日期:2008-06-01
卷期号:10
被引量:639
标识
DOI:10.1017/s1462399408000719
摘要
Galectins are a family of animal lectins that bind beta-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes. However, galectins are also detectable in the cytosol and nucleus, and may influence cellular functions such as intracellular signalling pathways through protein-protein interactions with other cytoplasmic and nuclear proteins. Current research indicates that galectins play important roles in diverse physiological and pathological processes, including immune and inflammatory responses, tumour development and progression, neural degeneration, atherosclerosis, diabetes, and wound repair. Some of these have been discovered or confirmed by using genetically engineered mice deficient in a particular galectin. Thus, galectins may be a therapeutic target or employed as therapeutic agents for inflammatory diseases, cancers and several other diseases.
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