生物
转化生长因子
转化生长因子β
自然杀伤细胞
锡克
细胞生物学
磷酸化
癌症研究
分子生物学
信号转导
体外
酪氨酸激酶
细胞毒性T细胞
生物化学
作者
Hae mi Lee,Kyung‐Sup Kim,Jongsun Kim
标识
DOI:10.1016/j.cellimm.2014.05.001
摘要
The major factors and mechanisms by which natural killer (NK) cells are inhibited in cancer patients have not yet been well defined. In this study, we conducted a comparative analysis of the effects of TGF-β, IL-10, and IL-4 on primary NK cells, and it was demonstrated that (1) TGF-β most potently inhibited the overall function of NK cells. (2) It appears that TGF-β reduced the tyrosine phosphorylation of Syk and the expression of c-myc. (3) It was also found that the IL-2-induced promoter-binding activities of C-myb, AP-1, CREB, and AR were also completely suppressed upon TGF-β treatment. Interestingly, TGF-β also completely suppressed other transcription factors, which are constitutively activated. Among these factors, we further confirmed roles of AP-1 in NK-92 cell activation through c-jun and MEK1 inhibitor assay. Our study provides insight into the effects of TGF-β in modulating NK cell functions.
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