光动力疗法
胶质瘤
细胞凋亡
内皮抑素
医学
癌症研究
血卟啉
裸鼠
体内
病理
血管内皮生长因子受体
癌症
化学
内科学
生物
生物化学
生物技术
有机化学
作者
Qimin Zhan,Yue Wu,Shaoshan Hu
标识
DOI:10.1016/j.pdpdt.2011.04.002
摘要
The aim of this study was to investigate the effect of endostar (a recombinant human endostatin) and photodynamic therapy (PDT) on gliomas. To establish glioma xenografts, human U251 glioma cells were injected into the brain of nude mice. Mice with MRI-confirmed glioma received hematoporphyrin monomethyl ether (HMME)-mediated PDT, daily injection of endostar or their combination, respectively. After treatment, tumor volume, the expression of HIF-1α, VEGF-A and apoptosis marker, and animal survival were examined. PDT and endostar treatment can prolong survival. Changes in induction of apoptosis, tumor growth and survival were more significant in PDT + endostar group. After PDT, HIF-1α and VEGF-A expressions were markedly increased. After endostar treatment, HIF-1α and VEGF-A expressions were significantly reduced. PDT in combination with endostar can significantly inhibit the growth of glioma xenografts. This approach may represent a promising strategy in the treatment of glioma.
科研通智能强力驱动
Strongly Powered by AbleSci AI