抗原
细胞毒性T细胞
生物
CD8型
免疫耐受
免疫系统
T淋巴细胞
分子生物学
抗原提呈细胞
白细胞介素21
T细胞
免疫学
体外
生物化学
作者
Susan R. Webb,Jonathan Sprent
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1990-06-29
卷期号:248 (4963): 1643-1646
被引量:98
标识
DOI:10.1126/science.1973003
摘要
Antigen-specific tolerance of T cells to minor lymphocyte stimulatory (Mls) antigens can be induced in mice by neonatal injection of foreign lymphohematopoietic cells. Although immune responses to Mlsa antigens are controlled by B cells, CD8+ T cells were the most effective cell type for induction of Mlsa tolerance. Tolerance was evident in both thymus and lymph nodes and could be induced by as few as 2 x 10(4) CD8+ T cells; these cells were 50 to 100 times as potent as CD4+ cells or B cells in causing functional tolerance and deletion of V beta 6+ T cells. Thus, intrathymic contact with antigens expressed on CD8+ T cells may play an important role in controlling the normal development of tolerance.
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