五素未翻译区
真核起始因子
起始因子
内部核糖体进入位点
翻译(生物学)
起始密码子
生物
真核翻译
三素数非翻译区
细胞生物学
平动调节
信使核糖核酸
核糖体结合位点
非翻译区
真核生物γ翻译起始因子4
EIF4A1
遗传学
EIF4E公司
核糖体
基因
核糖核酸
作者
Alan G. Hinnebusch,Ivaylo P. Ivanov,Nahum Sonenberg
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-06-17
卷期号:352 (6292): 1413-1416
被引量:831
标识
DOI:10.1126/science.aad9868
摘要
The eukaryotic 5′ untranslated region (UTR) is critical for ribosome recruitment to the messenger RNA (mRNA) and start codon choice and plays a major role in the control of translation efficiency and shaping the cellular proteome. The ribosomal initiation complex is assembled on the mRNA via a cap-dependent or cap-independent mechanism. We describe various mechanisms controlling ribosome scanning and initiation codon selection by 5′ upstream open reading frames, translation initiation factors, and primary and secondary structures of the 5′UTR, including particular sequence motifs. We also discuss translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and memory, neurodegenerative diseases, and cancer.
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