On the Security of Sulfonylurea in the Treatment of Type 2 Diabetes

Objective Sulfonylurea compounds are a large variety of drugs which are applied to clinical use very early.Although the hypoglycemic effect of the various kinds of sulfonylurea compounds is different,the hypoglycemic effect of each such compound is almost the same if its dose is properly adjusted.Therefore,sulfonylurea compounds play an important role in treating type 2 diabetes.Their antihyperglycemic mechanism is mainly to stimulate insulin to release so as to reduce the blood sugar.At present,it is the second-generation sulfonylurea compounds that are widely applied to clinical use.The rational use of the second-generation sulfonylurea compounds and the close observation of their security can reduce and evade severe drug adverse reaction.