Synthetic Strategies toward Higher Cocrystals of Some Resorcinols

Higher cocrystal synthesis depends on precise strategic approaches. A total of 32 stoichiometric ternary and quaternary cocrystals based on resorcinol derivatives were achieved using structural inequivalence and shape–size mimicry approaches and are reported here. Along with 28 binary precursors that were also obtained, these 60 cocrystals serve to generalize synthetic strategies toward these ends. A number of large synthon Aufbau modules (LSAMs) were designed depending on the substitution pattern in the resorcinol. The LSAMs from 5-substituted resorcinol were found to be useful in designing higher cocrystals. The construction of a stoichiometric quaternary cocrystal without the “special” compound 2,3,5,6-tetramethylpyrazine has been finally secured.