脂质运载蛋白
神经保护
缺血
体外
医学
大脑中动脉
电池极性
冲程(发动机)
细胞
化学
内科学
物理
生物化学
热力学
作者
Yongjun Cao,Zhiliang Guo,XU Guo-li,Jiaping Xu,Yaqian Huang,Chunfeng Liu
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2024-04-01
卷期号:23 (4): 525-535
被引量:3
标识
DOI:10.2174/1871527322666230417112850
摘要
background: Neutrophils and Lipocalin-2 (LCN2) play pivotal roles in cerebral ischemiareperfusion (I/R) injury. However, their contribution is not fully clarified. objective: This study aimed to explore the role of LCN2 and its association with neutrophil polarization in I/R injury. method: A mouse model of middle cerebral artery occlusion (MCAO) was used to induce cerebral ischemia. LCN2mAb was administered 1 h and Anti-Ly6G was administered for 3d before MCAO. The role of LCN2 in the polarity transition of neutrophils was explored using an in vitro HL-60 cell model. result: LCN2mAb pretreatment had neuroprotective effects in mice. The expression of Ly6G was not significantly different, but the expression of N2 neutrophils was increased. In the in vitro study, LCN2mAb-treated N1-HL-60 cells induced N2-HL-60 polarization. Conclusion: LCN2 may affect the prognosis of ischemic stroke by mediating neutrophil polarization.
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