SIRT3 deficiency exacerbates cognitive decline by disrupting mitochondrial antioxidant homeostasis in D-galactose-induced aging mice

SIRT3 is a critical regulator of hippocampal mitochondrial redox homeostasis. Augmenting hippocampal SIRT3 represents a promising therapeutic strategy for age-related cognitive impairment, supporting the translation of these findings to clinical interventions for neurological decline.