肿瘤微环境
材料科学
活性氧
细胞毒性T细胞
氧化应激
谷胱甘肽
免疫系统
癌细胞
癌症免疫疗法
过氧化氢
免疫疗法
生物物理学
癌症研究
癌症
化学
生物化学
生物
免疫学
酶
体外
遗传学
作者
Fei Gong,Muchao Chen,Nailin Yang,Ziliang Dong,Longlong Tian,Hao Yu,Ming‐Peng Zhuo,Zhuang Liu,Qian Chen,Liang Cheng
标识
DOI:10.1002/adfm.202002753
摘要
Abstract Modulating the hostile tumor microenvironment (TME) rather than directly killing cancer cells may be an effective strategy to improve the therapeutic benefits in cancer treatment. Herein, FeWO X nanosheets are constructed as cascade bioreactors to modulate the TME and enhance radiotherapy and immunotherapy of tumors. Synthesized by the thermal‐decomposition method and modified by poly(ethylene glycol) (PEG), the obtained FeWO X ‐PEG with multivalent metal elements (Fe 2+/3+ , W 5+/6+ ) exhibit efficient catalytic decomposition of hydrogen peroxide (H 2 O 2 ) to generate hydroxyl radicals (•OH) for chemo‐dynamic therapy (CDT). The generated high valence of metal ions (Fe 3+ /W 6+ ) in FeWO X ‐PEG are reduced by endogenous glutathione (GSH), both leading to depletion of GSH and further amplified oxidative stress, and resulting in the reduced metal valence statuses (Fe 2+ /W 5+ ) enabling cascade bioreactions. Such FeWO X ‐PEG bioreactors enhance the oxidative stress in the tumor and interact with X‐rays, significantly improving cancer radiotherapy (RT). Furthermore, the reactive oxygen species (ROS)‐induced inflammation caused by FeWO X ‐PEG in TME activates the immune system and promotes the tumor‐infiltration of various types of immune cells, which working together with cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) checkpoint blockade could elicits a robust immune response to defeat tumors.
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