Metformin added to intensive insulin therapy improves metabolic control in patients with type 1 diabetes and excess body fat

from the autoimmune destruction of pancreatic b cells, the major pathogenic factor in type 1 diabetes, there is accumulating evidence that insulin resistance is also involved in this disease and may influence metabolic control and risk of chronic complications. 3-6In patients with type 1 diabetes, insulin resistance may have genetic background (the concept of "double diabetes"), but often it is associated with unhealthy lifestyle (low physical activity, improper diet, smoking).Insulin therapy INTRODUCTION The increasing prevalence of diabetes and its chronic complications is an important public health concern. 1 The major contributor to this epidemiological trend is the increasing prevalence of type 2 diabetes related to the epidemic of obesity and insulin resistance.Nevertheless, the prevalence of type 1 diabetes is also increasing, and the phenomenon of insulin resistance may also contribute to this trend and modify the clinical picture of the disease. 2 Apart