The cognition, diagnosis and treatment of MODY2

Maturity-onset diabetes of the young (MODY) caused by glucokinase (GCK) gene mutation is called MODY2. Previous study has demonstrated that the levels of fasting blood glucose and glycated hemoglobin (HbA1c) in MODY2 increase slightly and keep stable. It will not raise the incidence of complications of diabetes and other related metabolic disease. Accordingly, there is no need to give treatment. But for pregnant women, if the fetus is without GCK gene mutation, the risk of macrosomia and perinatal morbidity will increase. Therefore, it is necessary to lower the level of blood glucose. Key words: Maturity-onset diabetes of the young 2; Diabetes mellitus; Glucokinase; Gene mutation