阿米卡星
医学
麻醉
经皮肾镜取石术
麻醉学
外科
入射(几何)
丸(消化)
安慰剂
经皮
光学
物理
抗菌剂
病理
有机化学
化学
替代医学
作者
Reetu Verma,Anil Agarwal,Prabhat Kumar Singh,Devendra Gupta,Rafat Shamim
出处
期刊:Anesthesia: Essays and Researches
日期:2016-01-01
卷期号:10 (3): 613-613
被引量:6
标识
DOI:10.4103/0259-1162.191116
摘要
Catheter-related bladder discomfort (CRBD) is the most distressing symptom in patients due to intraoperative urinary catheterization. Amikacin significantly inhibits detrusor contraction evoked by prejunctional stimulation.The aim of this study is to evaluate the efficacy of amikacin in prevention of CRBD in patients undergoing percutaneous nephrolithotomy.Study areas were operation theater and postanesthesia care unit of the Department of Anesthesiology, SGPGIMS, Lucknow.One hundred adult patients of either sex were randomly assigned into two groups of fifty each. Patients in control group received normal saline whereas patients in amikacin group received amikacin 10 mg/kg just before induction. Grading of CRBD was done as none, mild, moderate, and severe by a blinded observer at 0, 1, 6, 12, and 24 h after surgery.Data were analyzed using Student's t-test and Chi-square test among groups. Incidence of CRBD was compared with Chi-square test whereas severity was analyzed by the test of proportions (Z-test). Visual analog score was compared using Mann-Whitney U-test for surgical site pain.Incidence of CRBD in control group was 66% as compared to 44% observed in amikacin group (P < 0.05). During intergroup comparison at different time points, incidence of CRBD was reduced at 1 and 6 h in the amikacin group (P < 0.05). Significant reduction in the severity of CRBD (moderate) was also observed at 1 h in the amikacin group (P < 0.05). At rest of the time points, there was no significant difference.Amikacin can significantly reduce the incidence and severity of CRBD in the first few hours after surgery.
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