转移RNA
生物
脱甲基酶
血管生长素
核糖核酸
核糖体
假尿苷
长非编码RNA
蛋白质生物合成
细胞生物学
翻译(生物学)
非编码RNA
小核仁RNA
N6-甲基腺苷
生物化学
RNA结合蛋白
环状RNA
小RNA
信使核糖核酸
抄写(语言学)
RNA甲基化
基因沉默
RNA干扰
小RNA
小干扰RNA
基因敲除
遗传学
表观遗传学
基因
血管生成
作者
Zhuojia Chen,Meijie Qi,Bin Shen,Guan-Zheng Luo,Yingmin Wu,Jiexin Li,Zhike Lu,Zhong Zheng,Qing Dai,Hongsheng Wang
摘要
Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion. In vivo study confirms the regulation effects of ALKBH3 on growth of tumor xenograft. The m1A demethylated tRNA is more sensitive to angiogenin (ANG) cleavage, followed by generating tRNA-derived small RNAs (tDRs) around the anticodon regions. tDRs are conserved among species, which strengthen the ribosome assembly and prevent apoptosis triggered by cytochrome c (Cyt c). Our discovery opens a potential and novel paradigm of tRNA demethylase, which regulates biological functions via generation of tDRs.
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