葡萄糖激酶
糖尿病
糖酵解
内科学
内分泌学
细胞
医学
违反直觉
胰岛素
化学
生物化学
新陈代谢
认识论
哲学
作者
Marı́a S. Remedi,Colin G. Nichols
出处
期刊:Diabetes
[American Diabetes Association]
日期:2023-01-20
卷期号:72 (2): 170-174
摘要
Chronic hyperglycemia increases pancreatic β-cell metabolic activity, contributing to glucotoxicity-induced β-cell failure and loss of functional β-cell mass, potentially in multiple forms of diabetes. In this perspective we discuss the novel paradoxical and counterintuitive concept of inhibiting glycolysis, particularly by targeted inhibition of glucokinase, the first enzyme in glycolysis, as an approach to maintaining glucose sensing and preserving functional β-cell mass, thereby improving insulin secretion, in the treatment of diabetes.
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