New Strategy May Thwart Glioblastoma Resistance

Abstract A recent study demonstrates a new approach for targeting glioblastomas with faulty DNA repair pathways. Researchers synthesized a compound called KL-50 that creates a DNA lesion that becomes fatal to the cell if it is not repaired. KL-50 killed glioblastoma cells in which one key DNA repair protein was missing and an alternate repair mechanism didn’t work. The molecule also suppressed tumor growth in mice with implanted glioblastomas.