Evaluation of epidemiological and clinical features of respiratory viruses among hospitalized children

博卡病毒 偏肺病毒 鼻病毒 呼吸道感染 呼吸系统 肠道病毒 医学 病毒学 呼吸道 病毒 免疫学 内科学
作者
Deniz Aygün,Firuze Erbek,Mert Ahmet Kuşkucu,Dicle Şener,Muhammet Köşker,Fatih Varol,Kenan Midilli,Haluk Çokuğraş,Yıldız Çamcıoğlu
出处
期刊:Turk Pediatri Arsivi-turkish Archives of Pediatrics [KARE Publishing]
被引量:4
标识
DOI:10.14744/turkpediatriars.2020.39114
摘要

Acute respiratory tract infections are among the most common infectious diseases worldwide. Respiratory viruses are the leading cause of respiratory infections in children. Herein, we aimed to determine the epidemiologic and clinical feautures of viral agents among hospitalized children with lower respiratory tract infections.Nasopharyngeal swab specimens were obtained from the 422 patients hospitalized with a diagnosis of lower respiratory tract infections between December 2012 and December 2016. Multiplex reverse-transcription polymerase chain reaction was performed for the detection of viruses.Viral respiratory pathogens were detected in 311 patients (73.7%). In regard to respiratory virus subtypes, 103 patients (33.1%) had respiratory syncytial virus, 102 (32.7%) had human rhinovirus, 49 (15.7%) had multiple viruses, 15 (4.8%) had parainfluenzavirus, 13 (4.1%) had adenovirus, nine (2.8%) had human metapneumovirus, eight (2.5%) had human coronaviruses, six (1.9%) had bocavirus, five (1.6%) had influenza virus, and one patient (0.3%) had enterovirus. The median age was lower in patients with multiple viruses (p<0.001). The respiratory syncytial virus was more commonly detected in patients with a history of prematurity (p<0.001). Stridor was more common in other viruses including parainfluenza viruses (p<0.001).Respiratory viruses are the main causative agents of respiratory tract infections in children. Timely and accurate detection of viruses is necessary in terms of public health. The detection of respiratory viruses also contributes to epidemiologic results and vaccine studies.Solunum yolu enfeksiyonları tüm dünyada en yaygın görülen enfeksiyon hastalıkları arasındadır. Virüsler çocuklardaki solunum yolu enfeksiyonlarının en sık nedenidir. Bu yazıda, alt solunum yolu enfeksiyonu nedeniyle hastanede yatan çocuklarda viral etkenlerin epidemiyolojik ve klinik özelliklerinin incelemesi amaçlandı.Fakültemiz çocuk enfeksiyon servisinde Aralık 2012–Aralık 2016 tarihlerinde akut solunum yolu enfeksiyonları tanısı ile yatırılan 422 hastadan nasofarengeal sürüntü örneklemesi alındı. Virüslerin saptaması için multpileks polimeraz zincir reaksiyonu yöntemi kullanıldı.Viral solunum yolu virüsleri 311 hastada saptandı (%73,7). Solunum yolu virüslerinin tiplendirilmesi yapıldığında; 103 hastada (%33,1) respiratuvar sinsitiyal virüs, 102 hastada (%32,7) insan rinovirüs, 49 hastada (%15,7) çoklu virüs, 15 hastada (%4,8) parainfluenza virus, 13 hastada (%4,1) adenovirus, dokuz hastada (%2,8) metapnömovirüs, 8 hastada (%2,5) koronavirüs, altı hastada (%1,9) bokavirüs, beş hastada (%1,6) influenza virüsü ve bir hastada enterovirus saptandı. Çoklu virus saptanan hastaların yaşı daha küçüktü (p<0,001), respiratuvar sinsitiyal virüs prematürite öyküsü olan hastalarda daha sıktı (p<0,001). Stridor parainfluenza virus’da daha sık saptandı (p<0,001).Solunum virüsleri, çocuklarda solunum yolu enfeksiyonlarının ana nedenlerindendir. Toplum sağlığı açısından virüslerin zamanında ve doğru saptanması gerekmektedir. Solunum yolu virüslerinin saptanması epidemiyolojik sonuçlara ve aşı çalışmalarına da katkıda bulunmaktadır.
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