Hierarchical Glucose-Sensitive Hydrogel for Anti-IL-17 Antibody Delivery Enhances Alveolar Bone Regeneration in Diabetic Conditions

) at 2 weeks. Critically, immunofluorescence colocalization analysis provided direct spatial evidence that the hydrogel disrupted the pathogenic interaction between IL-17 and phosphorylated STAT3 within the defect microenvironment. By 8 weeks, micro-CT and histology revealed robust bone regeneration, characterized by mature collagen deposition and trabecular reconstruction. Immunohistochemistry confirmed persistent expression of osteogenic proteins (OPG, COL1A1). Major organs showed no pathological changes, confirming systemic biosafety. This glucose-responsive system integrates immunomodulation with osteogenic promotion, offering a promising strategy for diabetic bone repair by addressing the dual challenges of hyperglycemia and IL-17-mediated inflammation, thus presenting a targeted alternative to conventional growth factor-based therapies.