Cover Picture: Oxidative Metabolism of Ferrocene Analogues of Tamoxifen: Characterization and Antiproliferative Activities of the Metabolites (ChemMedChem 6/2015)

The front cover picture shows the cytochrome P450-dependent oxidation of ferrociphenols by rat and human liver microsomes. This oxidation leads to three main classes of metabolites: quinonemethides, indene compounds, and products derived from hydroxylation of the ethyl group. Ferrociphenols are known to exhibit antitumor activity against estrogen-independent breast cancer cells. Structural identification and synthesis of the major metabolites allowed their evaluation against a human breast cancer cell line, MDA-MB-231. A number of the metabolites exhibited remarkable antiproliferative effects toward MDA-MB-231 cells. For further details, see the Full Paper by Siden Top, Daniel Mansuy, Gérard Jaouen et al. on p. 981 ff.