Efficient Synthesis of 3‐Methyl‐Flavanones and Evaluation of Their Anti‐Bacterial Activity

Abstract A series of 2‐phenyl‐2,3‐dihydrochromon‐4‐one derivatives (flavanone derivatives) were synthesized by silica gel assisted isomerization of several α ‐methyl‐2′‐hydroxy chalcones in 74%–88% yield. These flavanones were further oxidized to 3‐methyl flavones by using iodine in dimethyl sulphoxide at 60°C in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus , Micrococcus luteus and Staphylococcus epidermis .