类风湿性关节炎
医学
免疫学
自身免疫
发病机制
促炎细胞因子
痹症科
细胞因子
白细胞介素17
白细胞介素23
关节炎
白细胞介素
人口
炎症
内科学
免疫系统
环境卫生
标识
DOI:10.1007/s11926-009-0052-y
摘要
Interleukin (IL)-17 (also known as IL-17A), the signature cytokine of the newly described T helper 17 (Th17) cell population, has been implicated in the pathogenesis of numerous autoimmune diseases including rheumatoid arthritis. IL-17 is the founding member of a new subclass of cytokines that have highly proinflammatory properties. Studies in rodents and mammalian cell culture systems, as well as clinical settings, support a role for IL-17 in promoting rheumatoid arthritis. This article discusses the history of the discovery of Th17 cells, the potential mechanisms of action of IL-17 in autoimmunity, and perspectives for IL-17-targeted cytokine therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI