Molecular Targets and Angiogenesis in Renal Cell Carcinoma, A Multitarget Approach: Mini Review

Background: Renal cell carcinoma (RCC) accounts for 2% of all adult malignancies and is associated with a case fatality rate as high as 40%. RCC has been on the rise for the last 6 decades at a steady increase of 2% per annum. Much work has been done to uncover the pathogenesis of the disease and the role of angiogenesis has been a recurrent denominator connected to vascular endothelial growth factor (VEGF) and its downstream effectors along with the mammalian target of rapamycin (mTOR) mediated signal transduction pathway. Keywords: Mammalian target of rapamycin, personalized medicine, angiogenesis, renal cell carcinoma, vascular endothelial growth factor, multi target approach.