Alcoholic liver disease serum TGF-β,IL-6 and IL-8 levels and its clinical significance

Objective To investigate the alcoholic hepatopathy patient serum transforming growth factor(transforming growth factor-β,TGF-β)interleukin-6(interleukin-6,IL-6)and interleukin-8(interleukin-8,IL-8)in alcoholic liver disease in rats.Methods 60patients with alcoholic liver disease patients with alcoholic fatty liver(n=20),alcoholic hepatitis(n=20)and alcoholic liver cirrhosis(n=20)were divided into three groups.ELISA method was used to detect20cases of healthy controls and 60patients with various types of alcoholic liver disease patients’serum TGF-β,IL-6and IL-8levels.Results the serum TGF-β,IL-6and IL-8levels with hepatic lesion severity increased,alcoholic fatty liver,alcoholic hepatitis group and the group of alcoholic cirrhosis group three index levels were higher than those in normal control group,significantly(P0.01),with alcoholic cirrhosis group three indicators for the highest level of.Conclusion TGF-β,IL-6and IL-8in alcoholic liver disease has important function in patients with alcoholic liver disease,serum TGF-β,IL-6and IL-8level detection can be used as alcoholic liver disease monitoring and prognostic index.