手性碳点在检测手性氨基酸中的应用研究进展

Abstract： Chirality is a fundamental property of living systems， and chiral amino acids differ markedly in bioactivi• ty， metabolism， and toxicological behavior； therefore， selective discrimination of amino acid enantiomers is of great importance in disease diagnosis， pharmaceutical analysis， and forensic identification.As an emerging class of zerodimensional nanomaterials， chiral carbon dots (Ch-CDs) combine excellent optical properties with favorable biocom • patibility and thus offer distinct advantages for enantioselective sensing.This review summarizes the chiral origins， synthetic strategies， recognition mechanisms， and sensing modes of Ch-CDs， with a focus on recent advances in the detection of representative amino acid enantiomers， including cysteine， lysine， tryptophan， arginine， and gluta• mine.Representative sensing strategies based on metal-ion mediation， metal-free recognition， ratiometric fluores• cence， and multimodal readout are systematically compared.Overall， Ch-CDs hold considerable promise for sensi• tive detection， portable signal readout， and analysis in complex matrices.However， their chirality-structure relation• ships， signal amplification mechanisms， and standardized evaluation criteria remain insufficiently understood， and some systems are still constrained by dependence on exogenous metal ions， limited anti-interference capability， and 文章编号： 1000-7032(XXXX)XX-0001-18