Redox-economical synthesis of α-substituted α-N-phthaloyl amino aldehydes using Fukuyama reduction

A three-step redox-economical synthesis of α-substituted α-N-phthaloyl aldehydes was developed using Fukuyama reduction from commercially available amino acids. The developed method provided various α-substituted α-N-phthaloyl aldehydes (16 entries) in 29–98 % yields. The developed protocol was reproducible on a large scale.