医学
冲程(发动机)
血管内治疗
缺血性中风
急诊医学
急性中风
心脏病学
外科
内科学
缺血
动脉瘤
组织纤溶酶原激活剂
机械工程
工程类
作者
Adrien E.D. Groot,Kilian M. Treurniet,Ivo G.H. Jansen,Hester F. Lingsma,Wouter H. Hinsenveld,Rob A. van de Graaf,Bob Roozenbeek,Hanna C. Willems,Wouter J. Schonewille,Henk A. Marquering,René van den Berg,Diederik W.J. Dippel,Charles B.L.M. Majoie,Yvo B.W.E.M. Roos,Jonathan M. Coutinho,Diederik W.J. Dippel,Aad van der Lugt,Charles B.L.M. Majoie,Yvo B.W.E.M. Roos,Robert J. van Oostenbrugge
出处
期刊:Neurology
[Lippincott Williams & Wilkins]
日期:2020-06-12
卷期号:95 (2)
被引量:66
标识
DOI:10.1212/wnl.0000000000009764
摘要
Objective
To explore clinical outcomes in older adults with acute ischemic stroke treated with endovascular thrombectomy (EVT). Methods
We included consecutive patients (2014–2016) with an anterior circulation occlusion undergoing EVT from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry. We assessed the effect of age (dichotomized at ≥80 years and as continuous variable) on the modified Rankin Scale (mRS) score at 90 days, symptomatic intracranial hemorrhage (sICH), and reperfusion rate. The association between age and mRS was assessed with multivariable ordinal logistic regression, and a multiplicative interaction term was added to the model to assess modification of reperfusion by age on outcome. Results
Of the 1,526 patients, 380 (25%) were ≥80 years of age (referred to here as older adults). Older adults had a worse functional outcome than younger patients (adjusted common odds ratio [acOR] for an mRS score shift toward better outcome 0.31, 95% confidence interval [CI] 0.24–0.39). Mortality was also higher in older adults (51% vs 22%, adjusted odds ratio 3.12, 95% CI 2.33–4.19). There were no differences in proportion of patients with mRS scores of 4 to 5, sICH, or reperfusion rates. Successful reperfusion was more strongly associated with a shift toward good functional outcome in older adults than in younger patients (acOR 3.22, 95% CI 2.04–5.10 vs 2.00, 95% CI 1.56–2.57, pinteraction = 0.026). Conclusion
Older age is associated with an increased absolute risk of poor clinical outcome, while the relative benefit of successful reperfusion seems to be higher in these patients. These results should be taken into consideration in the selection of older adults for EVT.
科研通智能强力驱动
Strongly Powered by AbleSci AI