Network pharmacology study on the mechanism of Shaoyao Gancao decoction in treating cancer pain

Objective: This paper aims to explore the key targets and mechanism of action of Shaoyao \nGancao Decoction in the treatment of cancer pain. Methods: TCMSP database was adopted to \nscreen the active components and potential targets of Shaoyao Gancao Decoction. Genecards \nand OMIM databases were used to collect disease targets for cancer pain. Cytoscape software \nwas used to construct the drug-component-target-disease network diagram. STRING database \nwas used to draw PPI network. Finally, gene ontology (GO) enrichment analysis and KEGG \npathway enrichment analysis were performed on key targets. Results: There were 98 potential \ntargets for the treatment of cancer pain in Shaoyao Gancao Decoction. The protein interaction \nnetwork suggested that IL-6, VEGFA, CASP3, EGFR and MAPK8 may be the core targets for \nthe treatment of cancer pain in Shaoyao Gancao Decoction. GO enrichment analysis showed \n127 cellular biological processes, and KEGG pathway enrichment analysis showed 116 related \nsignaling pathways, including MPAK, AGE-RAGE, TNF, ErbB and so on. Conclusions: The \ntreatment of cancer pain by Shaoyao Gancao Decoction may be multi-target, multi-channel \nand multi-level. This consequence may provide ideas and basis for further research.