生发中心
抗体
卵泡期
免疫学
生物
过继性细胞移植
细胞毒性T细胞
人口
CD40
滤泡树突状细胞
B细胞
先天性淋巴细胞
细胞
细胞生物学
获得性免疫系统
T细胞
免疫系统
抗原提呈细胞
医学
体外
环境卫生
生物化学
作者
Owen Jensen,Shubhanshi Trivedi,Jeremy D. Meier,Keke C. Fairfax,J. Scott Hale,Daniel T. Leung
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2022-01-14
卷期号:7 (67)
被引量:13
标识
DOI:10.1126/sciimmunol.abe8931
摘要
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in protection against bacterial pathogens at mucosal surfaces through the release of inflammatory cytokines and cytotoxic molecules. Recent evidence suggests that MAIT cells can also provide B cell help. In this study, we describe a population of CXCR5+ T follicular helper (Tfh)–like MAIT cells (MAITfh) that have the capacity to provide B cell help within mucosal lymphoid organs. MAITfh cells are preferentially located near germinal centers in human tonsils and express the classical Tfh-associated transcription factor, B cell lymphoma 6 (BCL-6), the costimulatory markers inducible T cell costimulatory (ICOS) and programmed death receptor 1 (PD-1), and interleukin-21 (IL-21). We demonstrate the ability of MAIT cells to provide B cell help in vivo after mucosal challenge with Vibrio cholerae. Specifically, we show that adoptive transfer of MAIT cells into αβ T cell–deficient mice promoted B cell differentiation and increased serum V. cholerae–specific IgA responses. Our data demonstrate the capacity of MAIT cells to participate in adaptive immune responses and suggest that MAIT cells may be potential targets for mucosal vaccines.
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