Expreesion of AXL and its significance in human glioma and meningioma

Objective: To investigate the expression of AXL in removed brain tissue of intracranial decompression,human gliomas,human meningiomas and the significance of AXL expression.Methods:31 tissue samples of glioma,25 tissue samples of meningioma patients and 12 removed brain tissue samples of intracranial decompression were collected and expressions of AXL in these tissue were detected using reverse transcriptase polymerase chain reaction(RT-PCR).Results:The positive expressions of AXL was found in removed brain tissue of intracranial decompression and human meningiomas tissue and there was no significant difference in expression between them(P0.05).The expression of AXL in human gliomas tissue was significantly higher than those in removed brain tissue of intracranial decompression and human meningiomas tissue(P0.05).Conclusion:The expression of AXL in human brain malignant tumor is higher than in benign tumor,indicating that AXL expression may be closely related to the nature of tumor.