上睑下垂
坏死性下垂
先天免疫系统
免疫系统
程序性细胞死亡
免疫学
CCL18型
先天性淋巴细胞
炎症
炎症体
免疫
获得性免疫系统
生物
模式识别受体
细胞凋亡
生物化学
作者
David E. Place,Thirumala‐Devi Kanneganti
标识
DOI:10.1016/j.coi.2020.10.013
摘要
The innate immune system, the first line of defense against pathogens and host tissue damage, initiates pro-inflammatory responses which, when dysregulated, promote inflammation to drive a broad range of autoimmune diseases. Immunomodulatory therapies have been developed to successfully treat several autoimmune diseases, but still many others lack effective treatments. Here, we explore recent advances in how the innate immune system contributes to autoinflammation, from the innate immune sensors that initiate immune responses to how this system regulates the activation of programmed cell death pathways including pyroptosis, apoptosis, necroptosis, and PANoptosis, which involves machinery from the pyroptotic, apoptotic, and necroptotic pathways. Recent advances in our understanding of innate immunity raise important considerations for developing new inflammatory disease treatments that target innate immune signaling and programmed cell death pathways.
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