甘露糖受体
受体
甘露糖
免疫系统
内吞循环
调节器
细胞生物学
促炎细胞因子
内吞作用
炎症
免疫学
生物
巨噬细胞
生物化学
体外
基因
作者
Hendrik J. P. van der Zande,Dominik Nitsche,Laura Schlautmann,Bruno Guigas,Sven Burgdorf
标识
DOI:10.3389/fimmu.2021.765034
摘要
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands. Because of these properties, its role in endocytosis as well as antigen processing and presentation has been studied intensively. Recently, it became clear that the mannose receptor can directly influence the activation of various immune cells. Cell-bound mannose receptor expressed by antigen-presenting cells was indeed shown to drive activated T cells towards a tolerogenic phenotype. On the other hand, serum concentrations of a soluble form of the mannose receptor have been reported to be increased in patients suffering from a variety of inflammatory diseases and to correlate with severity of disease. Interestingly, we recently demonstrated that the soluble mannose receptor directly promotes macrophage proinflammatory activation and trigger metaflammation. In this review, we highlight the role of the mannose receptor and other CLECs in regulating the activation of immune cells and in shaping inflammatory responses.
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